1.5 million people are living with HIV in Uganda, with only one in 10 getting the treatment they need. Young people are particularly vulnerable, 2.3% of young people are already living with the virus and only 35% know all the necessary facts to prevent HIV.

In 2014, the passing of the anti-homosexuality law has created a hostile environment for the LGBT community, making access to health information and services extremely difficult, and dangerous.

The Alliance has had a country office in Uganda since 2005 – Alliance Uganda - which in 2013 became an independent and autonomous organisation called Community Health Alliance Uganda (CHAU). CHAU provide direct services – in 2014 they provided testing and counselling for almost 70,000 people. Their work addresses the needs of young people as part of the Link Up project, an ambitious, five country programme which aims to improve the sexual and reproductive health and rights of more than one million young people over three years. They are also implementing the SHARP project which aims to improve the sexual health and rights of men who have sex with men.

Until June 2015 the secretariat of the Alliance maintained a small project office in Kampala to manage the USAID SUNRISE-OVC project. During the lifespan of the project, 374,000 orphans and vulnerable children directly benefited from services including child protection, withdrawal from child labour, family re-integration, arbitration and counselling, legal support, care and psychosocial services. Over 1 million children benefited indirectly from the project, which also strengthened government systems to support and safeguard orphans and vulnerable children.